Cannabidiol is the non-psychoactive component of the Cannabis Sativa plant however it is still pharmacologically active and is being found to be increasing useful to improve health and wellbeing. It has been shown to act as an agonist at the 5HT1a receptor1 which confers anxiolytic activity5. Due to its Serotonergic activity it has also demonstrated potential as a treatment for insomnia6 when taken correctly. Another study illustrated a reduction in stress for sufferers of PTSD which led to a reduction in ‘real nightmares’ and therefore an improvement in sleep7.
CBD acts as a partial agonist at the CB1 receptor and has additional activity at the TRPV1 receptor, it is this activity which has been shown to induce analgesia5.
Due to it’s efficacy as a broad spectrum pharmacological agent3 CBD has also demonstrated anti-inflammatory activity resulting in a decrease in pain for sufferers of osteoarthritis4.
Finally and most notably, compared to it’s psychoactive counterpart THC, Cannabidiol has the potential to increase wakefulness during daylight hours due to it’s effect on the dopaminergic system8.
Written by: Rachel Sawers MPharm MSc MRPharmS
On Behalf of: Fox Group International
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- Whiting, P.F., 2015. Cannabinoids for Medical Use A Systematic Review and Meta-analysis. The Journal of the American Medical Association, Vol 313, 2456-2473.
- Blessing et al, E.M,, 2015. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics, Vol 4, 825-836.
- Philpott et al, H.T., 2017. Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain, Vol 158 Issue 12, 2442-2451.
- 2018. Journals @ Ovid Full Text. [ONLINE] Available at: http://ovidsp.uk.ovid.com/sp-3.31.1b/ovidweb.cgi?&S=OFOHPDNEBHHFGDNEFNEKNDEGNLDBAA00&Complete+Reference=S.sh.23%7c2%7c1. [Accessed 19 October 2018].
- Babson, K.A., 2017. Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Current Psychiatry Reports, [Online]. 19, 23. Available at: https://link.springer.com/article/10.1007/s11920-017-0775-9#citeas [Accessed 19 October 2018].
- Carlin, E.A., 1981. Hypnotic and Antiepileptic Effects of Cannabidiol. The Journal of Clinical Pharmacology, Vol 21 Issue S1, 417S-427S.
- Murillo-Rodríguez, E.A., 2006. Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. Federation of European Biochemical Societies, Volume580, Issue18, 4337-4345.